A Systematic Approach to Identify Combinatory Small Molecules Which Can Synergistically and Selectiv

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Osteoblasts are specialized,terminally differentiated products of mesenchymal stem cells(Pittenger et al.,Science,1999).They synthesize very dense,crosslinked collagen,and several additional specialized proteins in much smaller quantities,including osteocalcin and osteopontin,which comprise the organic matrix of bone.This process is tightly regulated by multiple levels of regulatory systems,including microRNAs (miRNA).
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