Type 2 diabetes phenotypes are linked with cAMP content.cAMP is known to mitigate the metabolic actions of insulin in several cellular contexts and in several cases of physiological insulin resistance.In order to elucidate the regulatory mechanism for cAMP production in insulin-sensitive cells,we examined the roles of Gi2 protein and the A-Kinase Anchoring Proteins (AKAPs),which are responsible for inducing the multivalent signaling by association with various signaling elements including protein kinase A (PKA).