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Objectives Oxidative stress induces hypertrophic gene expression and collagen deposition that mediates cardiac hypertrophy and myocardial fibrosis.Vascular peroxidase 1 (VPO1) is a new heme-containing peroxidase, which can utilise hydrogen peroxide (H2O2) generated from co-expressed NADPH oxidase (NOX) to produce hypochlorous acid (HOC1) and catalyse peroxidative reactions.