INVOLVEMENT OF VASCULAR PEROXIDASE 1 IN ANGIOTENSIN II-INDUCED H9C2 CELLS HYPERTROPHY

来源 :第二十四届长城国际心脏病学会议、亚太心脏大会暨国际心血管病预防与康复会议(The 24th Great Wall Int | 被引量 : 0次 | 上传用户:aa9294168
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Objectives Oxidative stress induces hypertrophic gene expression and collagen deposition that mediates cardiac hypertrophy and myocardial fibrosis.Vascular peroxidase 1 (VPO1) is a new heme-containing peroxidase, which can utilise hydrogen peroxide (H2O2) generated from co-expressed NADPH oxidase (NOX) to produce hypochlorous acid (HOC1) and catalyse peroxidative reactions.
其他文献
Objectives To explore the regulating lipid effects of Rosuvastatin on rats with dyslipidemia and its antiatherosclerotic effects.Methods Thirty-six mate SD rats were randomly divided into normal group
会议
Objectives Renin-angiontensin-aldosterone system (RAAS) is widely evidenced its point on inhibiting ventricular remodelling post myocardial infarction.The increasing expression of angiotensin and angi
会议
Objectives To evaluate the dynamic change of DNP contents both in the plasma and LV of SHRs and to explore the role of DNP in the development of hypertension and left ventricular hypertrophy (LVH).Met
会议
Objectives To access the therapeutic effects of renal sympathetic denervation (RSD) onpost-myocardial infarction (MI) ventricular remodelling in canine, the most optimal time for treatment, and discus
会议
Objectives To observe the expression and anti-apoptosis role of microRNA-21 (miR-21) in rat myocardium during early ischaemia-reperfusion injury (I/R).Methods Sprague-Dawley rats were randomly divided
会议
Objectives To observe the effect of Ruanmailing component of traditional Chinese medicine on the reorganisation of cofilin,twinfilin-1, profilin-1 induced by platelet-derived growth factor (PDGF) in v
会议
Objectives Silencing Geminin gene selectively by using RNA interference and investigate the mechanism of the Geminin gene silence regulating VSMCs proliferation.Methods VSMCs proliferation were determ
会议
Objectives Renal ischaemia/reperfusion (I/R) injury is a common clinical disease.We have known that NO-signal transduction has an important effect on renal I/R injury.NO is produced by NO synthases.En
会议
Objectives Renal ischaemia reperfusion injury (IRI) causes renal tubular necrosis, apoptosis and inflammation leading to acute kidney dysfunction.Recent studies suggest knockout of Gα12 protects from
会议
Objectives To investigate the stimulative effect of D3 dopamine receptors on the insulin-like growth factors-1 (IGF-1)-induced vascular smooth muscle cells (VSMCs) migration and the mechanism underlyi
会议