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Objective:To study the rat intestinal absorption characteristic of archen and emodin monomethyl ether of the total anthraquinone of Polygonum cuspidatum and the total anthraquinone of Polygonum cuspidatum solid lipid nanoparticles(SLN)prepared by film-ultrasonic dispersion method in situ;Study the influence of intestinal absorption process that P-glycoprotein presenced in intestinal epithelial cells for archen and emodin monomethyl ether in total anthraquinone of Polygonum cuspidatum and the total anthraquinone of Polygonum cuspidatum SLN.