DNA 的超长度和双螺旋性质使其在在复制、转录和基因表达的过程中需要不断地进行超螺旋和解旋状态之间的转换,在这一过程中,DNA 拓扑异构酶(topoisomerase,Topo)可催化改变 DNA 的拓扑结构,解决构象转换问题。研究表明,Topo 在肿瘤细胞中表现出高表达,因此,可以通过影响Topo 酶的作用过程来抑制酶的活性,进而达到抗肿瘤的效果。
Pancreatic cancer is one of the deadliest cancer with high metastasis rate and a dismal prognosis.Integrins,a class of transmembrane protein,are generally overexpressed in pancreatic tumors and play f
B cell-activating factor(BAFF)plays a fundamental role in B lymphocyte survival and homeostasis,and aberrant BAFF signalling is closely related to numerous autoimmune disorders.
Oxidative stress imbalance has always been considered as a crucial mechanism going with myriads of clinical diseases.As antioxidant therapy is emerging as an innovative strategy,nanoantioxidants posse
Endogenous G-quadruplex(G-4)aptamers can regulate various biological processes,through the direct interaction to target protein,affecting the genetic transcription,replication and translation.
Curcumin has been widely reported as potential anticancer candidate drugs that can inhibit the clonogenicity of cancer cells and induce anti-proliferative and apoptotic effects on drug-resistant cance