NIFEVIROC,a new and potent small-molecule inhibitor targeted at the human immunodeficiency virus typ

来源 :中国科协青年科学家论坛暨2006年第二届新生病毒性疾病控制学术研讨会 | 被引量 : 0次 | 上传用户：frankfeir

【摘要】

：

【作者】

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Li Chen Gang Pei Dawei Ma Renhai Chen Li Liu Qing Fang Zhiwei Chen Linqi Zhang

【机构】

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Shanghai TargetDrug Co.Ltd Shanghai Institute of

【出处】

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中国科协青年科学家论坛暨2006年第二届新生病毒性疾病控制学术研讨会

【发表日期】

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2006年1期

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　　NIFEVIROC, a small molecular compound, is a proprietary drug candidate which is developed by TARGETDRUG and holds great promise in inhibiting HIV-1 replication in infected paitents.Preclinical studies suggested that NIFEVIROC is a specific CCR5 antagonist determined by multiple receptor functional assays.In addition, NIFEVIROC demonstrated potent inhibition activity against HIV-1 entry into the target cells by effectively blocking the human CCR5 receptors on the cell membrane.Furthermore, NIFEVIROC showed strong antiviral activity against wide variety of HIV strains, including those multi-drug resistant mutants.

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