Objective To evaluate the possible changes of total and regional areas in the corpus callosum(CC)of first-episode schizophrenic patients of early adulthood onset and to explore the relationship between area changes of CC and clinical variables in schizophrenia group.Methods 42 first-episode schizophrenic patients and 32 age,sex and education matched controls were selected for the study.Magnetic resonance images were collected using GE 3.0T scanner.Sagittal images were acquired through Three-Dimensional FSPGR sequence and mid-sagittal slices were chosen.Mid-sagittal slices were analyzed by the Scoin image software,which divided CC into seven subdivisions (rostrum,genu,rostral body,anterior mid-body,posterior mid-body,isthmus,and splenium) based on the principles of Witelsons method.Areas of total and sub-regions of CC were compared between the patients and controls.The correlations between area changes of CC and clinical variables (including illness duration and PANSS scores)were evaluated.Results No significant difference of callosal areas was found between patients and controls(P<0.05).Area of CC did not show any significant correlation with clinical variables(γ<0.4,P<0.05). Conclusions Our results show no obvious CC morphological changes of first-episode schizophrenic patients of early adulthood onset.No significant correlation is showed between callosal areas and illness duration,which is supportive of the theory that the disorder has neurodevelopmental origins.