【摘 要】
：
Aim: To study the plasma protein binding rate of puerarin.Methods: The microdialysis-HPLC method was applied to determine the plasma protein binding rate of puerarin.Results: The plasma protein bindin
【机 构】
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School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310013,China
【出 处】
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The 12th Meeting of the Asia Pacific Federation of Pharmacol
论文部分内容阅读
Aim: To study the plasma protein binding rate of puerarin.Methods: The microdialysis-HPLC method was applied to determine the plasma protein binding rate of puerarin.Results: The plasma protein binding rate of puerarin with rate plasma at the concentration of 20, 60, and 200 μg/mL were 34.86％, 33.82％, and 25.09％, respectively, while the plasma protein binding rate of puerarin with normal human plasma at the above concentrations were 31.69％, 31.02％, and 22.90％, respectively.Conclusion: Puerarin belongs to low protein bounding drugs.
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