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  5. Entry of Bombyx mori nucleopolyhedroviruse (BmNPV) into BmN Cells by cholesterol-dependent macropino

Entry of Bombyx mori nucleopolyhedroviruse (BmNPV) into BmN Cells by cholesterol-dependent macropino

来源 :中国蚕学会第八届青年学术研讨会 | 被引量 : 0次 | 上传用户：kyzy0082
【摘 要】
：
BmNPV is a serious viral pathogen of silkworm,and no drug or specific protection is available at present time.Although most genes’ function of BmNPV was depicted in recent years,knowledge on BmNPV ent
【作 者】
：
Jinshan Huang Bifang Hao Xingjia Shen Chen Cheng Fei Liang Shengpeng Wang 
【机 构】
：
College of Biotechnology, Jiangsu University of Science and Technology;Sericultural Research Institu
【出 处】
：
中国蚕学会第八届青年学术研讨会
【发表日期】
：
2014年10期
【关键词】
：
BmNPV Macropinocytosis Endocytosis Cholesterol 
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　　BmNPV is a serious viral pathogen of silkworm,and no drug or specific protection is available at present time.Although most genes’ function of BmNPV was depicted in recent years,knowledge on BmNPV entry into cells is still limited.Here BmNPV cell entry mechanism is investigated by different endocytic inhibitor application and subcellular analysis.Results indicated that BmNPV enters BmN cells by clathrin-indepedent macropinocytic endocytosis,which is mediated by cholesterol in a dose dependent manner,and cholesterol replenishment rescued the BmNPV infection partially.
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