Background/Aims: No clinical model exists to predict the occurrence of hepatocellular carcinoma in sustained virologic response-achieving (HCC after SVR) patients with chronic hepatitis C (CHC).Methods: We perfomed a casecontrol study using a clinical database to research the risk factors for HCC after SVR.A predictive model based on risk factors was established,and the area under the receiver operating characteristic curve (AUC) was calculated.Results: In the multivariate model,an initial diagnosis of compensated cirrhosis and post-SVR albumin reductions of 1 g/L were associated with 21.7-fold (95% CI,4.2 to 112.3;p<0.001) and 1.3-fold (95% CI,1.1 to 1.7;p=0.004) increases in the risk of HCC after SVR,respectively.A predictive model based on an initial diagnosis of compensated cirrhosis (yes,+1;no,0) and post-SVR albumin ≤36.0 g/L (yes,+1;not,0) predicted the occurrence of HCC after SVR with a cutoff value of >0,an AUC of 0.880,a sensitivity of 0.833,a specificity of 0.896,and a negative predictive value of 0.956.Conclusions: An initial diagnosis of compensated cirrhosis combined with a post-SVR albumin value of ≤36.0 g/L predicts the occurrence of HCC after SVR in patients with CHC.