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  5. A gap junction docking mechanism revealed by functional rescue of a disease-linked connexin mutant

A gap junction docking mechanism revealed by functional rescue of a disease-linked connexin mutant

来源 :The 4th International Ion Channel Conference(第四届国际离子通道会议) | 被引量 : 0次 | 上传用户：bigxiong
【摘 要】
：
The docking of two hemichannels to form a functional gap junction (G J) channel is only possible between compatible connexins (Cxs), but the underlying molecular mechanism is unclear.Based on Cx26 GJ
【作 者】
：
Xiang-Qun Gong So Nakagawa Tomitake Tsukihara Donglin Bai 
【机 构】
：
The University of Western Ontario London, Ontario, Canada
【出 处】
：
The 4th International Ion Channel Conference(第四届国际离子通道会议)
【发表日期】
：
2013年2期
【关键词】
：
gap junction docking heterotypic channel connexin26 connexin32 
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The docking of two hemichannels to form a functional gap junction (G J) channel is only possible between compatible connexins (Cxs), but the underlying molecular mechanism is unclear.Based on Cx26 GJ crystal structure we developed homology models for homotypic and heterotypic channels from Cx32 and/or Cx26;these models predict 6 hydrogen bonds (HBs) at the docking-interface of each pair of the second extracellular domains (E2).
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