2. 您的位置
3. 首页
4. 会议论文
5. Genome-wide CNV analysis in mouse induced pluripotent stem cells reveals dosage effect of pluripoten

Genome-wide CNV analysis in mouse induced pluripotent stem cells reveals dosage effect of pluripoten

来源 :The 7th Guangzhou International Conference on Stem Cell and | 被引量 : 0次 | 上传用户：dcqnj

【摘 要】

：

Background:Induced pluripotent stem cells (iPSCs) derived from somatic cells have enormous potentials for clinical applications.Notably,it was recently reported that reprogramming from somatic cells t

【作 者】

：

Yulin Chen Lin Guo Jiekai Chen Xiangjie Zhao Weichen Zhou Cheng Zhang Jiucun Wang Li Jin Duanqing Pei Feng Zhang 

【机 构】

：

State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary

【出 处】

：

The 7th Guangzhou International Conference on Stem Cell and

【发表日期】

：

2014年5期

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

Background:Induced pluripotent stem cells (iPSCs) derived from somatic cells have enormous potentials for clinical applications.Notably,it was recently reported that reprogramming from somatic cells to iPSCs can induce genomic copy number variation (CNV),which is one of the major geneticcauses of human diseases.

其他文献

Salvianolic Acids Attenuate Rat Hippocampal Injury after Acute CO Poisoning by Improving Blood Flow

Abstract:Carbon monoxide(CO)poisoning causes the major injury and death due to poisoning worldwide.The most severe damage via CO poisoning is brain injury and mortality.Delayed encephalophathy after a

会议

Carbon monoxide poisoningHemorheologySalvianolic acidsMalondialdehyde

Cell Therapy and Cellular Organelle Replacement for Prevention and Treatment of Refractory and Incur

The field of cell therapy and organelle replacement is rapidly growing.We focus on stem cell therapy and mitochondrial replacement in order to discuss the challenges and successes of what it takes to

会议

Identification and functional characterization of lncRNAs in skeletal muscle cells and muscle regene

Emerging studies document the roles of long non-coding RNAs (LncRNAs) in regulating gene expression at chromatin level but relatively less is known how they regulate DNA methylation.Here we identify a

会议

Epigenetic determinants of stem cell commitment and differentiation skeletal muscles

We will present our latest studies on the epigenetic control of gene expression that underlies embryonic and adult stem cell differentiation into the skeletal muscle lineage,with a special focus on th

会议

Generation of Special ADPKD-iPS Cells from an ADPKD Family without PKD1/2 Gene Defect Along with Eff

Background:With the identical genome from parent cells,induced pluripotent stem cells (iPSCs) technology have no doubt become a novel powerful cell model in vitro for investigating the genesis and pro

会议

Ex vivo expansion of functional human UCB-HSCs/HPCs by co-culture with AFT024- hkirre cells

Kiaa 1867(human Kirre,hKirre) has a critical role in brain development and/or maintenance of the glomerular slit diaphragm in kidneys.Murine homolog of this gene,mKirre expressed in OP9 and AFT024 cel

会议

CHD1L knockdown significantly inhibits human embryonic stem cell self-renewal

Overexpression of CHD1L (chromodomain helicase/ATPase DNA binding protein 1 like gene) is highly associated with poor prognosis in many malignancies.However,the function of CHD1L in human Embryonic St

会议

Generation of Functional Human Cardiac Progenitor Cells by High Efficiency Protein Transduction

Cardiac progenitor cells (CPCs) potentially offer a novel approach to cardiovascular regeneration.The reprogramming of fibroblasts to induced pluripotent stem cells (iPSCs) raises the possibility that

会议

JMJD3 NEGATIVELY REGULATES REPROGRAMMING BY PROMOTING INK4A/ARF EXPRESSION AND TARGETING PHF20 FOR U

Although somatic cell reprogramming can be achieved by several strategies,its efficiency and kinetics of iPSC generation are still very low,suggesting the existence of substantial genetic and epigenet

会议

Insulin Enhances Diabetic Bone Repair through Regulating Glut1 Expression

Insufficient insulin production or action in diabetic states is associated with growth retardation and impaired skeletal tissue repair or delayed fracture union,but the mechanisms responsible for thes

会议