虽1986 年、1996 年世界卫生组织(WHO)发行第一版、第二版癌症治疗,建议类鸦片药物(opioids)按口服、按时,按三阶段方式给予,可解除75 %-85 %癌症疼痛,但剩余15 %-25 %癌症疼痛仍须以fentanyl 贴片、皮下/静脉注射opioids、脊髓注射opioids、神经阻断/神经破坏方式治疗.
Drug transporters are proteins of transmembrane transport in all organs of human. Active transport is its major function.
High mobility group protein 1 and 2 (HMGB1 and HMGB2) are 80% conserved in amino acid sequence.
Hepatocellular Carcinoma (HCC) is the fifth most common cancer and the second most frequent cause of death from cancer worldwide.
Platinum response severely impedes successfully chemotherapy in lung cancer patients.
Drug induced liver injury (DILI), which nowadays is well accepted to include drugs and natural toxins (such as herbal remedies and dietary supplements) induced liver injury, is a severe and potentiall
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection.
The impact of gut microbiota on the response and metabolism of xenobiotics has been extensively investigated and recognized in recent decades. In particular, gut microbiota have been found to exert va
Bilirubin-related adverse reactions (ADR, e.g., jaundice and hyperbilirubinemia) induced by herbs rich in certain polyphenolic acids are widely reported.
UDP-glucuronosyltransferase (UGT) 1A1-catalyzed glucuronidation is an important elimination pathway of flavonoids, and mutually inhibitory interactions may occur when two or more flavonoids are coadmi