【摘 要】
:
In contrast to animal models, human solid tumors are the products of long term co-evolution between the cancer cells and host immune systems, and can often be anatomically classified into different ar
【机 构】
:
Sun Yat-sen University, Guangzhou, 510060,P.R.China
论文部分内容阅读
In contrast to animal models, human solid tumors are the products of long term co-evolution between the cancer cells and host immune systems, and can often be anatomically classified into different areas, each with distinct compositions and functional properties.
其他文献
Background: Emerging evidence indicates that nerve damage-initiated neuroinflammation and immune responses, which are evidenced by the up-regulation of proinflammatory cytokines, contribute to the dev
Background: Hydrogen sulfide (H2S), an endogenous gaseotransmitter/modulator, is becoming appreciated that it may be involved in a wide variety of processes including inflammation and chronic.
Human T lymphocytes, bearing T-cell receptor (TCR) γδ, play an important role in tumor immunosurveillance and antitumor immune responses.Functionally, without negative selection during thymus developm
Emerging evidence indicates that nerve damage-initiated neuroinflammation and immune response, which are evidenced by the up-regulation of proinflammatory cytokines, contribute to the development of n
Mas oncogene-related G protein-coupled receptor C (MrgC) is unequally expressed in sensory ganglia and has been shown to modulate pathologic pain.This study investigated the mechanism underlying the e
CD38, a cell surface enzyme expressed by Multiple Myeloma and Chronic Lymphatic Leukemia cells, is a target antigen for therapeutic antibodies.Nanobodies, single domain antibodies derived from llama h
Arthritis is characterised by both inflammation and the destruction of cartilage and bone.Current treatments target inflammation.They have to be administered life-long, are burdened with potentially s
In the cancer tissue, except for neoplastic cells, there are different kinds of stromal cells, such as fibroblasts, endothelial cells as well as hematopoietic pro-inflammatory cells.Fibroblasts, which
Immune responses to cancer are highly complex.Classic analytic approaches, i.e.flow cytometry, can only follow a limited amount of immune cells at a given time.Further the staining panel limits the su
CD8+ T lymphocytes (CTL) can exert potent in vivo cytotoxicity against autologous melanoma cells.However, T-cell activity is impaired when poorly immunogenic tumor phenotypes evolve in the course of d