2-Aminoalkanesulfonic acids,such as taurine and substituted taurines,are a class of important naturally occurring amino acids and sulfur analogs of naturally occurring protein-encoded amino acids as well.They show various biological activities such as enzyme inhibitors,phosphorylation regulators,etc.Recently,our group has developed a series of methods to synthesize structurally diverse 1-and 2-monosubstituted,1,1-,1,2-,and 2,2-disubstituted taurines from simple starting materials.They show strong self-assembled property in MALDI-TOF analysis,for example,see Fig.1.They generally show two series of self-assembled peaks,[M+H]+,[2M+H]+,[3M+H]+,[4M+H]+,[5M+H]+,….; and [M+Na]+,[2M+Na]+,[3M+Na]+,[4M+Na]+,[5M+Na]+,….,indicating that substituted taurines assemble linear complexes through triple O-H-N hydrogen bonds.