【摘 要】
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A series of novel compounds(8a-21b)were designed and synthesized based on lH-benzo[d]imidazole.Their biological activities were evaluated as potential tubulin polymerization inhibitors and anticancer
【机 构】
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State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,Nanjing 210093,People's Rep
【出 处】
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第八届国际分子模拟与信息技术应用学术会议
论文部分内容阅读
A series of novel compounds(8a-21b)were designed and synthesized based on lH-benzo[d]imidazole.Their biological activities were evaluated as potential tubulin polymerization inhibitors and anticancer agents.Among all the compounds,compound 18b showed the most potent in vitro growth inhibitory activity against A549,MCF-7,K562 cancer cell lines,with IC50 values of 0.12 μM,0.15 μM,0.21 μM,respectively.And,compound 18b also exhibited significant tubulin polymerization inhibitory activity(IC50=2.1 μM),which was comparable with the positive control.Furthermore,docking simulation and 3D-QSAR modeling of inhibitor analogues provide determination of the probable binding model and an important basis that compound 18b with potent inhibitory activity in tumor growth may be a potential anticancer agent.
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