【摘 要】
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OBJECTIVE:Oxaliplatin is a commonly used drug for chemotherapy in digestive tract malignant tumors.But its side of effect on peripheral neuropathy has no effective treatment.This type of solving one p
【机 构】
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Oncology Department, Clifford Hospital of Guangzhou University of Chinese Medicine,Guangzhou 511495,
【出 处】
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世界中联自然疗法研究专业委员会第五届学术年会暨国际热疗医学学会第35届学术年会
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OBJECTIVE:Oxaliplatin is a commonly used drug for chemotherapy in digestive tract malignant tumors.But its side of effect on peripheral neuropathy has no effective treatment.This type of solving one problem but introducing another new problem seriously affects the quality of life and the continuation of chemotherapy.METHODS:There are totally 88 cases of colon cancer,rectal cancer and gastric cancer,all being diagnosed by pathological.These patients are treated with oxaliplatin protocols which contains chemotherapy.After treatment,they have been randomly selected to the treatment group of 45 cases and the control group of 43 cases.The treatment group is given modified Taohongsiwu decoction to soak hands and feet,once a day.The control group was given glutathione orally.The assessment of peripheral neuropathy takes NCI WHO Eloxatin special evaluation standard of classification.RESULTS:For the treatment group,the classification of peripheral neuropathy degradation was decreased,and Common Peroneal nerve and Tibial nerve of sensory nerve and motor nerve conduction velocity being increased significantly,which has statistical significance.Also,dramatic improvements have been observed between the two groups in pain relief,quality of life in the following categories have also been improved:Daily life,gymnastics,sleeping patterns and interpersonal communication in work places also improved(P<0.01).However,the research shows no significant differences in the capabilities of driving or interpersonal relationships with others.CONCLUSION:Modified Taohongsiwu decoction is effective in the treatment of patients with peripheral neuropathy caused by oxaliplatin.
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