Objective Introduction Microbubbles are widely used as ultrasound contrast agents owing to their excellent echoing characteristics under ultrasound radiation.However,conventional techniques for fabricating microbubbles generally result in broad size distribution (1 ~10 μm),which directly related to resonant frequency and ultrasound enhanced efficiency.Moreover,Traditional lipid microbubbles do not provide a strong enough barrier to retain their enhanced ultrasound imaging capabilities for a sufficient length of time under high-power irradiation.Their short sonographic duration and wide size distribution still hinder their application.Thus, developing a simple strategy to create uniform microbubbles, which can provide enhanced contrast of backscattering signal and high structural stability is still the hot and difficult subject in this field.