【摘 要】
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Objective The treatment of liver diseases associated with chronic hepatitis B virus (HBV) infection has become a major clinical challenge, partly due to the many drug-resistant HBV mutants induced by
【出 处】
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中华医学会第四届全国病毒性肝炎慢性化、重症化基础与临床研究进展学术会议
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Objective The treatment of liver diseases associated with chronic hepatitis B virus (HBV) infection has become a major clinical challenge, partly due to the many drug-resistant HBV mutants induced by wide application of nucleoside/nucleotide analogues.Currently the rate of resistance to adefovir dipivoxil (ADV) is relatively low, but in China is steadily increasing.We investigated the loci of ADV-induced resistance of HBV isolates obtained from patients with chronic HBV infection-related liver diseases.
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目的 乙型肝炎病毒感染是全球性的公共卫生问题,终末期肝病的死亡率高达70％以上,而以肝衰竭占多数,此类患者病情发展迅速,在患者住院早期需临床医生对病情做出预后判断,采取合理治疗方案.目前临床工作逐渐发现MELD评分存在多适用于国外酒精性肝病进展的肝衰竭病人,且不能反应腹水等肝硬化的并发症.因此积极探索肝衰竭新的预警指标和早期诊断方法是肝病工作者关注的重点课题之一.
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