Expression of synuclein gamma indicates poor prognosis of triple negative breast cancer

来源 :2013中国普外科焦点问题学术论坛 | 被引量 : 0次 | 上传用户:tangtieming1983
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Background Synuclein gamma (SNCG), previously identified as breast cancer specific genel (BCSG1), is highly expressed in malignant cells but not in normal epithelium.The present studies demonstrated that the expression of SNCG is an independent predictive marker for recurrence and metastasis in breast cancer.Triple-negative breast cancer (TNBC), are characterized by a lack of expression of both Estrogen Receptor (ER) and Progesterone Receptor (PgR) as well as HER-2, often associated with particularly poor outcomes and early development of chemotherapy resistance, lack of targeted therapy.This study is to reveal if SNCG-positive TNBC is more likely than SNCG-negative TNBC to have a more aggressive phenotype.
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