【摘 要】
：
Molecules possessing 2(5H)-furanone moiety are receiving increasing attention due to the significant biological activities,such as antifungal,antibacterial,anti-inflammatory,and anticancer.1 At the sa
【机 构】
：
School of Chemistry and Environment, South China Normal University;Key Laboratory of Theoretical Che
【出 处】
：
中国化学会第十三届全国有机合成化学学术研讨会
论文部分内容阅读
Molecules possessing 2(5H)-furanone moiety are receiving increasing attention due to the significant biological activities,such as antifungal,antibacterial,anti-inflammatory,and anticancer.1 At the same time,many 3,4-dihalo-2(5H)-furanone compounds are important synthons in organic synthesis and material preparation.2 Recently,we found a new catalyst-free three-component reaction for the preparation of important compounds arylsulfonyl dibromomethanes without the needs of anaerobic atmosphere from sodium arylsulfinate 1,3,4-dibromo-5-hydroxy-2(5H)-furanone 3 (X =Br,R =OH) and solvent DMSO (2).3 Herein,we further found that other 3,4-dihalo-2(5H)-furanone derivatives 3 also could take part in this mild metal-free three-component reaction to synthesize arylsulfonyl dihalomethanes 4.However,the yields were affected by 5-position functional group slightly while halogen kinds seriously.
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