【摘 要】
:
CD44 is type-1 transmembrane glycoprotein mediating the response of cells to their cellular microenvironment (1).CD44 proteins participate in many cellular processes,including the regulation of growth
【机 构】
:
Beijing Proteome Research Center,National Key Laboratory of Proteomics,Beijing,100850,China
【出 处】
:
第七届中国蛋白质组学大会暨第三届国际蛋白质组学论坛
论文部分内容阅读
CD44 is type-1 transmembrane glycoprotein mediating the response of cells to their cellular microenvironment (1).CD44 proteins participate in many cellular processes,including the regulation of growth,survival,differentiation and motility.
其他文献
结核分枝杆菌耐药突变的快速诊断对结核病的早期有效治疗和控制至关重要,然而传统的结核杆菌药敏试验需要长达几周的时间,所以我们需要新的方法减少诊断时间,缩小传播的范围.本研究将基于单碱基延伸的基因分型方法应用于结核分枝杆菌耐药性基因突变的快速检测中,我们主要针对六个基因的耐药突变,这些基因有:rpoB, rpsL, rrs,embB, katG,和inhA.此方法用耐药性突变基因的PCR扩增产物为模板
肝炎性病毒感染严重影响着人类生命健康,但迄今仍缺乏能真实反映病毒与宿主之间相互作用的研究模型。建立能够真实反映肝炎性病毒与人肝脏细胞相互作用的细胞模型对肝炎性病毒致病机制和抗病毒新药的开发具有重要意义。我们开展了应用人胚胎干细胞定向分化获得的肝脏细胞建立肝炎病毒感染模型的研究,成功的应用人胚胎干细胞建立了HCV感染复制体外模型,该模型能够支持HCV完整的生命周期(包括新产生病毒的释放)。研究发现H
随着干细胞技术的发展,应用干细胞建立疾病模型为相关疾病致病机制的研究提供了新的契机。我们初步探索了应用人胚胎干细胞来源的肝细胞作为乙肝病毒(H3v)体外研究模型的潜力。定向分化人胚胎干细胞为肝细胞(hESC-Heps);采用免疫荧光方法检测肝性因子如肝细胞核因子-4α(HNF4α)、白蛋白(ALB)和HBV功能性受体钠离子/牛磺胆酸共转运蛋白(NTCP)受体的表达;实时荧光定量PCR检测Ⅲ型干扰素
Hepatitis C virus (HCV) hijacks host lipid metabolism for its infection.However, this mechanism remains poorly understood.We previously reported that HCV replication requires hepatocyte nuclear factor
Human lung adeno-carcinoma is one of the most aggressive cancers in the world,with a high incidence and mortality rate.The major obstacle in the field is the late diagnosis due to the highly heterogen
Protein phosphorylation plays a critical role in the regulation of many cellular functions.Analysis of phosphoproteomes by mass spectrometry depends on many factors,in particular an efficient method t
The neural potential of pluripotent neural stem cells (NSCs) makes them a promising source for cell-based therapy of neural tissue damage.However,the exact intracellular molecular mechanisms of neural
Protein acetylation has emerged as a major mechanism in regulating cellular metabolism(1-3).Whereas most glycolytic steps are reversible,the reaction catalyzed by pyruvate kinase is irreversible and t
Of the 20 ribosomally coded amino acid residues,lysine is the most frequently post-translationally modified,which has important functional and regulatory consequences.Here we report the identification
Glycosylation is one of the most important and common forms of protein posttranslational modifications,which is involved in many physiological functions and biological pathways.