【摘 要】
：
Objective: To investigate whether AG490 combined with regular chemotherapy and targeted drugs may provide a new therapeutic approach for the treatment of DLBCL.Methods: DLBCL cells cultured in RPMI-16
【机 构】
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Department of Medical Oncology,Sun Yat-Sen University,Guangzhou,China;State Key Laboratory of Oncolo
【出 处】
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22nd Asia Pacific Cancer Conference(第22届亚太抗癌大会)
论文部分内容阅读
Objective: To investigate whether AG490 combined with regular chemotherapy and targeted drugs may provide a new therapeutic approach for the treatment of DLBCL.Methods: DLBCL cells cultured in RPMI-1640 medium were treated with the JAK inhibitor AG490 and/or adriamycin(ADM), etoposide (VP-16), vincristine (VCR), rituximab, and temsirolimus (CCI-779) at different concentrations for 72.The cytotoxic activities were evaluated using MTT cell viability assay in human DLBCL cell lines OCI-lyl, OCI-ly8, OCI-ly19, SUDHL-4, and NU-DHL-1 cells.The apoptosis of the cells was analyzed using flow cytometry.The expressions of LC3, p62,caspase-3, and PARP proteins were detected using Western blot.
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