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5. Design,Synthesis,and Structure-Activities Relationship Studies of α7 Nicotinic Acetylcholine Recepto

Design,Synthesis,and Structure-Activities Relationship Studies of α7 Nicotinic Acetylcholine Recepto

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：yhj740821

【摘 要】

：

Nicotinic acetylcholine receptors(nAChRs)are members of Cys-loop ligand gated ion channels superfamily.The α7 nAChR,a homopentamer composed of five α7 subunits,has been implicated in diseases associat

【作 者】

：

Qing Li Yu Xue Taoyi Yang Xiaozhuo Ma Kewei Wang Liangren Zhang 

【机 构】

：

School of Pharmaceutical Science,Peking University Health Science Center Xueyuan Road,Haidian Distri

【出 处】

：

2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

【关键词】

：

alpha7 nAChR agonists indolizine SAR TEVC 

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　　Nicotinic acetylcholine receptors(nAChRs)are members of Cys-loop ligand gated ion channels superfamily.The α7 nAChR,a homopentamer composed of five α7 subunits,has been implicated in diseases associated with cognitive impairment such as Alzheimers disease and schizophrenia.

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