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  5. piRNA-mediated cleavage of messenger RNAs and long non-coding RNAs

piRNA-mediated cleavage of messenger RNAs and long non-coding RNAs

来源 :第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会 | 被引量 : 0次 | 上传用户：ndhlps
【摘 要】
：
Background: The piRNA machinery is well known for its role in mediating epigenetic silencing of transposons and recent studies suggest that this function may also involve piRNA-guided cleavage of tran
【作 者】
：
张鹏 付向东 刘默芳 何顺民 康俊严 苟兰涛 王佳佳 薛元超 Geir Skogerboe 戴鹏 黄大卫 陈润生 
【机 构】
：
进化与系统学重点实验室,中科院动物所,北京,100101 病毒学国家重点实验室,武汉大学生科院,武
【出 处】
：
第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
【发表日期】
：
2014年4期
【关键词】
：
piRNA Miwi protein long non-coding RNA gene regulation 
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　　Background: The piRNA machinery is well known for its role in mediating epigenetic silencing of transposons and recent studies suggest that this function may also involve piRNA-guided cleavage of transposon-derived transcripts.As many piRNAs appear to have the capacity to target diverse mRNAs and long non-coding RNAs (lncRNAs), it raises an intriguing possibility that piRNAs may extensively act like siRNAs to degrade specific mRNAs and long non-coding RNAs.
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