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The purpose of this study was to investigate the effect of solvents on the formation thermodynamics of myricetin-caffeine(MYR-CAF)cocrystal.Solubilities of MYR,CAF and MYR-CAF cocrystal in three different solvents(i.e.methanol,ethanol and acetone)were determined and the complexation type of cocrystal in solvents was also explored.