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The transient analysis for output voltage of a piezoresistive microaccelerometer takes a relatively high computational cost because at least two iterations are required to calculate the piezoresistive-structural coupled response at each time step.The high computational cost for calculating the transient output voltage can be highly reduced by a way of using Krylov-based model order reduction and the least square method.In the approach, data on static displacement and output voltage calculated by piezoresistive-structural coupled simulation for three acceleration inputs are used to develop a quadratic regression model relating the output voltage to the displacement at a certain observation point.The transient output voltage is then calculated by the regression model using the displacement response cheaply calculated by the reduced-order models.A high-G piezoresistive microaccelerometer with various input accelerations was studied to represent the efficiency and accuracy of the suggested approach.