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5. Design,synthesis,and biological evaluation of carbohydrate-based carbonic anhydrase Ⅸ inhibitors

Design,synthesis,and biological evaluation of carbohydrate-based carbonic anhydrase Ⅸ inhibitors

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：wangligang987123

【摘 要】

：

Carbonic anhydrases(CAs)are a family of enzymes comprised of 16 isoenzymes that can catalyze the hydration of carbon dioxide to a proton and bicarbonate anion and therefore play an important role in t

【作 者】

：

Zhuang Hou Xinxin Zhang Fengran Li Yang Liu Maosheng Cheng Chun Guo 

【机 构】

：

Key Laboratory of Structure-Based Drug Design & Discovery(Shenyang Pharmaceutical University),Minist

【出 处】

：

2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

【关键词】

：

Carbonic anhydrase Ⅸ Sugar scaffolds Membrane impermeability Selectivity 

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　　Carbonic anhydrases(CAs)are a family of enzymes comprised of 16 isoenzymes that can catalyze the hydration of carbon dioxide to a proton and bicarbonate anion and therefore play an important role in the regulation of the intracellular and extracellular pH value[1].

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