HBeAg阳性慢乙肝患者恩替卡韦与长效干扰素(Peg-IFN)alfa-2a联合序贯治疗的持续应答OSST研究随访一年结果分析

来源 :中华医学会第四届全国病毒性肝炎慢性化、重症化基础与临床研究进展学术会议 | 被引量 : 0次 | 上传用户:ARMYUN1981
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目的 OSST多中心随机对照研究表明,对于长期服用恩替卡韦治疗而没有获得HBeAg血清学转换的慢乙肝患者,采用恩替卡韦与长效干扰素(Peg-IFN) alfa-2a联合/序贯治疗组(短暂联合8周后即转为单用长效干扰素治疗,总疗程48周)比继续单用恩替卡韦治疗组在48周时可获得更高的HBeAg转换率和HBsAg阴转率.本研究主要观察恩替卡韦转换为长效干扰素组(即联合/序贯治疗组)治疗结束后随访一年的血清学应答率.
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