Objective To observe clinical therapeutic effect of transcutaneous electrical acupoint stimulation on inflammation and the function of pulmonary Gas Exchange in the patient with tourniquet on the lower limb.Methods Forty patients undergoing unilateral lower extremity surgery with tourniquet were randomly assigned into TEAS group and I/R group.The TEAS group received transcutaneous electrical acupoint stimulation at the acupoint ST36 and SP6 with the frequency of 2/15 Hz and maximum tolerance intensity 30 minutes before operation.The I/R group received minimum intensity.In both groups, the MAP (Mean arterial pressure) and HR (heart rate) were recorded at T0 (before TEAS), T1 (5min after induction), T2 (1minutes before loosen the tourniquet), T3 (1 minutes after loosen the tourniquet), T4 (5 minutes after loosen the tourniquet) and T5 (6hours after loosen the tourniquet).Arterial blood samples were cannulated at T0 and T5 for gas analysis, which include PaO2, a/A ratio, PA-aDO2 and respiratory index(RI).And the serum IL-6, IL-10, TNF-α and MCP-1 were also measured by ELISA.Results The content of IL-6 and MCP-1 at T5 were increased compared with T0 in I/R group, (P < 0.05).And the levels of IL-6 and MCP-1 in TEAS group were decreased compared with I/R group at T5,which was also seen same tendency about the levels of TNF-a.Compared with T0, PaO2 and a/A ratio were decreased, PA-aDO2 and RI were increased in group I/R.In group TEAS,PaO2 and a/A ratio were decreased, PA-aDO2 and RI were increased compared with group I/R at T5.Conclusions TEAS reduces the proinflammatory factors whicn was product by limb ischemia-reperfusion ,and improve the function of pulmonary gas exchange.