【摘 要】
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Objective:Epidemiological studies had suggested that lycopene intake could lower blood pressure,but the results were conflicting.Our present study aimed to establish the effect of lycopene supplement
【机 构】
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School of Public Health,Medical College of Soochow University,Suzhou 215123,Jiangsu,China;School of
【出 处】
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2012第二届中韩植物化学物国际学术研讨会
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Objective:Epidemiological studies had suggested that lycopene intake could lower blood pressure,but the results were conflicting.Our present study aimed to establish the effect of lycopene supplement on blood pressure by conducting a meta-analysis of intervention trials.Methods:PubMed database was screened to search for intervention studies evaluating the effect of lycopene on blood pressure with a minimum duration of 2 weeks through February 2012.Meta-analysis was conducted by using random effect model to to calculate the combined effect size.Additionally,subgroup analysis stratified by baseline blood pressure,lycopene dosage and duration were also conducted.Results:Five studies met inclusion criteria,and the pooled analysis demonstrated a significant reduction of blood pressure (mean SBP =-4.815 [-8.618,-1.012],p =0.009,mean DBP =-2.249 [-4.218,-0.279],p =0.025).Obvious heterogeneity was observed (P=0.000,I2=64.3 %).Results of subgroup analysis displayed that lycopene significantly lowered blood pressure among participants with baseline SBP>120mmHg,DBP>80mmHg (mean SBP =-5.638 [-9.504.-1.772],mean DBP =-2.350 [-4.404,-0.295]),furthermore,the higher dosage of lycopene,with the longer intervention period could lowver blood pressure more significantly.
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