Hepatic macrophages are the largest nonparenchymal cells group in liver.Recent research have found that hepatic macrophages had different functions in different stages of liver fibrosis in different animal models of liver fibrosis.Why and how hepatic macrophages had double sword function in liver fibrosis are not fully understand.Some studies found there are different types of hepatic macrophages in liver,but other studies argue hepatic macrophages can transform themselves in different environments.This article will review these remarkable research in hepatic macrophages in liver fibrosis,and give the potential targets to treat liver fibrosis though the pathogenesis of hepatic macrophages.