非天然氨基酸的合成研究

来源 :华东理工大学 | 被引量 : 0次 | 上传用户:hjx9062
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N-烷基-α-氨基酸和β-氨基酸是改造肽和蛋白质的两类主要方法.该文设计了多条路线合成了16只光学活性的非天然氨基酸及其它们的衍生物.11只未见文献报导.5只已知的化合物不仅制备方法得到改进,产率提高,而且都得到了晶体.该文对天冬酰胺在Arndt-Eistert反应中的副反应机理进行了探讨.经过初步的研究,该文确定了制备Z保护的β-氨基酸的最佳方法.该文共合成了16种化合物,并对两种反应的机理进行了探讨.该文所合成的化合物经熔点、纯度(HPLC)、旋光度、红外、核磁、质谱得到证实.
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