Objective: 1. To ascertain TRPC3 and TRPC6 expression on right ventricle. 2.To observe the effect of three dlifferent hypertensive drugs on their expression　　 Method: 24 sixteen weeks old spontaneous hypertensive rats (SHR) and 6 age-matched Wistar-Kyoto (WKY) rats were prepared. SHR furtherdivided into 4 groups (n=6) consisted of SHR group and 3 treatment groups of Amlodipine 5mg/kg/d, Ramipril 5mg/kg/d, and valsartan 30 mg/kg/d. Afterward, caudal systolic blood pressure and body weight were recorded each day for l month. TRPC3 mRNA expression was assessed with RT-PCR. Imaging and densitometry were performed with BioRad imaging software. The data are presented as the mean+SD and compared using two-tailed student T-test, Significance is determined at the p<0.05 level.　　 Result: TRPC3 mRNA is highly expressed on right ventricle of SHR. Treatment resulted in normalization of blood pressure on all treatment groups. Amlodipine reduced TRPC3 expression (80.3367±2.05038, p<0.05)more than Valsartan (176.8067±2.05038, p<0.05) or ramipril (127.0283±3.96995, p<0.05). No TRPC6 expression detected on rightventricle of WKY, SHR, or combined treated groups at the end of the experiment.　　 Conclusion: 1. TRPC3 was highly expressed on right ventricle of hypertensive ratssignified susceptibility to future insult. Treatment results instatistically significant reduction of TRPC3 mRNA level in alltreatment groups,　　 2. Amlodipine may decrease expression of TRPC3 mRNA on rightventricle of SHR partly independent of its blood pressure loweringeffects.