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目的评价肾移植术后针对供肾者特异性HLA抗体对移植肾免疫反应的影响。方法采用前瞻性队列研究,通过抗体监测系统(AntibodyMonitoringSystemAMS)检测125例首次肾移植患者术前、术后针对供肾者特异性抗体水平,随访观察针对供肾者特异性HLA抗体对肾移植免疫反应的影响。结果术后针对供肾者特异性抗体阳性组发生免疫反应率高于阴性组(P<0.005)。按照针对供肾者特异性HLA-类和类抗体水平分组后,移植肾无排斥存活率依次为:HLA--/-组>HLA--/+组>HLA-+/-组>HLA-+/+组。结论针对供肾者特异性HLA抗体可能是引起移植肾免疫反应的原因之一,HLA-类抗体与免疫反应关系较为密切。
Objective To evaluate the effect of donor-specific HLA antibodies on renal allograft immune response after renal transplantation. Methods A prospective cohort study was conducted to detect the levels of specific antibodies against the kidneys in 125 patients with primary renal transplant recipients by Antibody Monitoring System Antibody Monitoring System (ANSG). Follow-up was conducted to investigate the effects of donor-specific HLA antibodies on renal allograft immune response Impact. Results The postoperative immunoreactivity of the antibody specific to the donor kidney was higher than that of the negative group (P <0.005). According to the levels of specific HLA- and anti-HLA antibodies, the graft-free survival rates were: HLA - / -> HLA - / +> HLA - + / -> HLA- / + Group. Conclusion HLA-specific antibodies against the kidneys may be one of the causes of renal allograft immune response. HLA-antibodies are closely related to the immune response.