目的分析不同时期登革热确诊患者的发病特征及其差异,为临床辨证论治提供依据。方法收集2013年、2014年广州市荔湾区确诊为登革热患者的临床资料,对不同年份患者的年龄、性别、发病时间、临床表现进行比较。结果共收集2013年257例、2014年465例登革热患者。2013年患者中,男148例,女109例,年龄10~84岁;2014年患者中,男227例,女238例,年龄12~92岁,两年的患者年龄及性别比较,2013年患者年龄偏低,且男性患者比例较高,差异均有统计学意义(P<0.05)。2013年、2014年登革热发病的高峰均发生在10月,但2013年发病的次高峰在11月,2014年的次高峰在9月,两年发病的时间分布比较差异有统计学意义(P<0.05)。2014年登革热患者出现纳差、皮疹、身重乏力、肌痛/骨痛的比例高于2013年(P<0.05)。结论登革热发病具有不同的人群特征、时间特征、临床特征,应结合气候、物候、病候辨治。 Objective To analyze the incidence characteristics and differences of patients diagnosed with dengue in different periods and provide basis for clinical syndrome differentiation. Methods The clinical data of patients with dengue fever diagnosed in Liwan District of Guangzhou City in 2013 and 2014 were collected. The age, sex, onset time and clinical manifestations of patients were compared in different years. Results A total of 257 cases in 2013 and 465 cases in 2014 were collected. In 2013, there were 148 males and 109 females, aged from 10 to 84 years. In 2014, 227 males and 238 females aged 12 to 92 years and two years were compared in age and sex. In 2013, patients The age was low, and the proportion of male patients was higher, the differences were statistically significant (P <0.05). In 2013 and 2014, the peak incidence of dengue occurred in October, but the sub-peak incidence in 2013 was in November and the sub-peak in 2014 was in September and the difference in incidence of two-year incidence was statistically significant (P < 0.05). In 2014, the incidence of anorexia, rash, fatigue, and myalgia / bone pain were higher in dengue patients than in 2013 (P <0.05). Conclusion The incidence of dengue fever has different population characteristics, time characteristics, clinical features, should be combined with climate, phenology, disease differentiation.