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目的拉考沙胺是一个新的用于治疗癫痫的辅助药物,也用于糖尿病神经疼痛的单一治疗。拉考沙胺选择性增强钠通道慢失活,同时也作用于塌陷反应调节蛋白-2,拉考沙胺口服吸收迅速完全,半衰期长达13 h,与药物相互作用少,药动学为线性,在临床试验中表现出良好的抗癫痫效果以及耐受性,笔者综述了其药理作用、作用机制、药动学、疗效评价以及安全性。
Aims Lacusamide is a new adjuvant for the treatment of epilepsy and is also used as a monotherapy for diabetic neuropathic pain. Raclotamide selectively increases slow sodium channel inactivation and also acts on collagenous response regulator protein-2, and lacosamide is rapidly absorbed orally, with a half-life of up to 13 h, little interaction with the drug and a linear pharmacokinetic profile , In clinical trials showed good antiepileptic effect and tolerance, the author reviewed its pharmacological effects, mechanism of action, pharmacokinetics, efficacy evaluation and safety.