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在自然界中,复杂天然产物的精巧组装往往令人叹为观止.如何在化学实验室里模拟生物合成的过程、高效地制备具有类似生物功能的化合物一直是科学家们长久以来的梦想.天然有机化合物的仿生合成是近年来备受关注的热点领域之一.中国科学院上海有机化学研究所洪然等科研人员基于碳阳离子参与的环化反应的可能生物合成机制,发展了简洁高效的百部酰胺(Stemoamide)仿生合成路线,以8步反应37%的总收率获得了消旋的百部酰胺,为该
In nature, the delicate assembly of complex natural products is often amazing.How to simulate the biosynthesis process in a chemical laboratory and to efficiently prepare compounds with similar biological functions has long been the dream of scientists.Physics of natural organic compounds Synthesis is one of the hot areas of great concern in recent years.Hong Ran et al., Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, have developed a simple and efficient Stemoamide based on the possible biosynthesis mechanism of the cyclization reaction involving the carbon cation. Biomimetic synthesis route, racemization of the amide amide was obtained in 37% overall yield in 8 steps,