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内皮素(endothelin,ET)是血管内皮细胞产生的具有强烈缩血管作用的生物活性多肽。循环内皮素水平异常在许多心血管疾病中具有重要发病学意义,但内皮素的生物学效应至今尚未完全阐明,尤其是对心肌细施代谢的影响未见报道。本工作在离体Langendorff灌流的大鼠心脏和心肌肌膜(sarcolemmal membrane,SL)蛋白
Endothelin (ET) is a biologically active polypeptide produced by vascular endothelial cells and having a vasoconstrictor effect. Circulating endothelin levels abnormal in many cardiovascular disease has important significance in the pathogenesis, but the biological effects of endothelin has not yet been fully elucidated, in particular, the impact of myocardial metabolism of metabolism has not been reported. This work in vitro Langendorff perfused rat heart and cardiac muscle (sarcolemmal membrane, SL) protein