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目的研究原发性肝(PHC)癌患者不同水平甲胎蛋白(AFP)与甲胎蛋白异质体(AFP-L3)、高尔基体蛋白73(GP73)以及α-L-岩藻糖苷酶(AFU)三者异常率的相关性。方法临床纳入我院2012年6月至2015年6月期间收治的原发性肝癌42例(观察1组)、慢性肝炎40例(观察2组)以及肝硬化46例(观察3组),另选取40例同期来我院进行体检的健康人(对照组)。对4组对象血清AFP、AFP-L3、GP73以及AFU水平进行检测,观察不同AFP水平与AFP-L3、GP73以及AFU水平异常率的相关性。结果三组患者AFP、AFP-L3以及GP73水平均高于对照组(P<0.05)。观察1组AFP、AFP-L3明显高于观察2组、观察3组(P<0.05);观察1组、观察2组GP73水平无差异(P>0.05),但明显低于观察3组(P<0.05)。三组患者异常率明显高于对照组(P<0.05);观察1组患者AFP异常率高于观察2组、观察3组(P<0.05);观察1组AFP-L3异常率大于观察2组、观察3组(P<0.05);观察1组、观察2组GP73异常率小于观察3组(P<0.05);观察1组、观察3组AFU异常率小于观察2组(P<0.05)。随着AFP水平的升高,AFP-L3、AFU异常率不断上升,两者呈正相关;而与GP73异常率无相关性。而在AFP<100 ng/m L时,AFP-L3异常率小于GP73和AFU异常率(P<0.05)。结论 AFP-L3对原发性肝癌诊断价值较高,而GP73更适合对肝硬化患者进行诊断。
Objective To investigate the effects of different levels of AFP and AFP-L3, GP73 and α-L-fucosidase (AFU) in patients with primary liver cancer (PHC) ) Abnormal rate of the three correlations. Methods Forty-two cases of primary hepatocellular carcinoma (group 1), 40 cases of chronic hepatitis (group 2) and 46 cases of cirrhosis (group 3) were enrolled in our hospital from June 2012 to June 2015. Forty healthy subjects (control group) were selected for physical examination in our hospital. The serum levels of AFP, AFP-L3, GP73 and AFU in 4 groups of subjects were measured to observe the correlation between different levels of AFP and abnormal rates of AFP-L3, GP73 and AFU. Results The levels of AFP, AFP-L3 and GP73 in the three groups were significantly higher than those in the control group (P <0.05). The level of AFP-L3 in group 1 was significantly higher than that in group 2, and the level of AFP-L3 in group 1 was significantly higher than that in group 2 (P <0.05) <0.05). The abnormal rate of AFP in observation group 1 was higher than that in observation group 2 and the observation group 3 (P <0.05). The abnormal rate of AFP-L3 in observation group 1 was higher than that in observation group 2 (P <0.05). The abnormal rate of GP73 in observation group 1 was less than that in observation group 3 (P <0.05). In observation group 1, the abnormal rate of AFU in observation group 3 was less than that in observation group 2 (P <0.05). With the increase of AFP level, the abnormal rate of AFP-L3 and AFU was rising, which showed a positive correlation between them. However, there was no correlation between them and the rate of GP73 abnormality. However, at AFP <100 ng / m L, the abnormal rate of AFP-L3 was less than that of GP73 and AFU (P <0.05). Conclusions AFP-L3 is more valuable for the diagnosis of primary liver cancer, while GP73 is more suitable for the diagnosis of patients with cirrhosis.