Lockwood等报道了在肺出血肾炎综合征(Goodpasture’s syndrome)时,应用充分的血浆交换、类固醇制剂和细胞毒药物的联合治疗,获得了令人鼓舞的疗效。在治疗后,肺出血减少,肾功能得到改善(在无重症肾功能衰竭的患者)。Hammersmith医院的研究人员对这些显著的优点提出了两种可能的机制:(1)除去了血循环中抗肾小球基底膜的抗体。(2)减少了炎性介质如纤维蛋白原和补体。最近,Lockwood等又报道了9例急进型“半月体型”肾炎的治疗效果,这一类型肾炎的致病并不是由于血循环中抗肾小球基底膜的抗体的作用,而猜想是由于血循环中 Lockwood et al. Reported encouraging results with the combination of adequate plasma exchange, steroid formulations and cytotoxic drugs in the treatment of Goodpasture’s syndrome. After treatment, pulmonary bleeding is reduced and renal function is improved (in patients without severe renal failure). Researchers at Hammersmith Hospital have proposed two possible mechanisms for these salient advantages: (1) antibodies against the glomerular basement membrane in the circulation have been removed. (2) reduce the inflammatory mediators such as fibrinogen and complement. Recently, Lockwood et al reported the treatment of 9 cases of acute type “half body” nephritis, the pathogenesis of this type of nephritis is not due to blood circulation in the anti-glomerular basement membrane antibodies, and the conjecture is due to blood circulation