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双嘧哒莫(潘生丁)片是一心血管药物,广泛用于抗血小板凝集,预防血栓形成、动脉硬化以及心肌梗塞复发等疾病。《中国药典》95年版收载的含量测定方法是采用分光光度法,但在实际工作中发现,用此法进行含量测定,由于潘生丁遇光不稳定,样品溶液具有荧光,受其干扰,测得的吸光度值不稳定,致使含量测定结果偏低,重复性相对较差。如果对半成品颗粒的含量控制不准确,就不能准确指导车间压片。本文通过对同一样品分别采用分光光度法和容量分析法进行含量测定比较,
Dipyridamole (dipyridamole) tablets is a cardiovascular drug, widely used in anti-platelet aggregation, prevention of thrombosis, atherosclerosis and myocardial infarction recurrence and other diseases. “Chinese Pharmacopoeia” 95 edition contained content determination method is the use of spectrophotometry, but in the actual work found that using this method for the determination of the content, due to dipyridamole light instability, the sample solution has fluorescence, by its interference, measured Of the absorbance value is unstable, resulting in lower content determination, repeatability is relatively poor. If the semi-finished product particle content control is not accurate, it can not accurately guide the workshop tableting. In this paper, by the same sample were measured by spectrophotometry and volumetric content comparison,