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目的观察支气管哮喘应用白三烯拮抗剂(孟鲁斯特钠)联合吸入沙美特罗氟替卡松治疗的临床效果。方法 108例支气管哮喘患者,依据随机双盲法将其分为对照组和研究组,各54例。对照组患者予以沙美特罗氟替卡松治疗,研究组患者在对照组基础上联合孟鲁斯特钠治疗,观察两组临床疗效。结果治疗后研究组患者的肺功能各项指标均超过对照组患者(P<0.05);且治疗后研究组患者在各阶段的临床症状积分均比对照组低(P<0.05);研究组和对照组患者在治疗期间不良反应情况比较差异无统计学意义(P>0.05)。结论支气管哮喘应用白三烯拮抗剂联合吸入沙美特罗氟替卡松治疗的临床效果显著,能有效改善患者的肺功能。
Objective To observe the clinical effect of leukotriene antagonist (montelukast sodium) in combination with inhaled salmeterol fluticasone in bronchial asthma. Methods One hundred and eighty patients with bronchial asthma were divided into control group and study group according to randomized double-blind method, 54 cases in each. Patients in the control group were treated with salmeterol fluticasone. The study group was treated with montelukast sodium on the basis of the control group, and the clinical efficacy was observed. Results After treatment, the indexes of pulmonary function in study group were higher than those in control group (P <0.05). After treatment, the score of clinical symptom of study group was lower than that of control group (P <0.05) There was no significant difference in adverse reactions among the control group patients during the treatment (P> 0.05). Conclusion The clinical efficacy of leukotriene antagonist combined with inhaled salmeterol fluticasone in bronchial asthma is significant, which can effectively improve the pulmonary function of patients.