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nel样Ⅰ型基因是一种在颅缝早闭者早闭区过度表达的新型基因,因其具有极强的诱导成骨细胞分化和促进新骨形成的生物学功能,被作为新型生长因子用于骨组织工程。本文就nel样Ⅰ型基因成骨及其在骨组织工程中的应用等研究进展作一综述。
The nel-like gene, type I, is a novel gene overexpressed in the early-closed area of craniosynostosis. It has been used as a novel growth factor because of its strong biological function of inducing osteoblast differentiation and promoting new bone formation In bone tissue engineering. This article reviews the research progress of nel-like type Ⅰ gene osteogenesis and its application in bone tissue engineering.