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在昼夜10个时点,观察了模拟海拔10000m高原(大气压等于26.7kPa)急性缺氧60min时小白鼠活存数与死亡动物的活存时间。从凌晨3:00起,小白鼠活存数开始增加,死亡动物的活存时间开始延长,并于5∶30达到最高值。随后,活存数虽维持在同一水平,而死亡动物的活存时间则逐渐缩短。两者在14:56-0:30间处于最低值。结果表明:①小白鼠对急性缺氧的耐受性具有昼夜节律变化;②以夜间活动的啮齿类动物为实验研究对象时,应注意昼夜节律对研究结果的影响。
At 10 days and nights, the live survival time of mice and the survival time of dead animals were observed at 60 min simulated acute altitude of 10000m altitude (atmospheric pressure equal to 26.7kPa). From 3:00 am onwards, the survival of mice began to increase, dead animals began to live longer, and reached the highest value at 5:30. Subsequently, although the number of surviving remained at the same level, the survival time of the dead animals was gradually shortened. Both are at a minimum between 14: 56-0: 30. The results showed that: (1) circadian rhythm changes in the tolerance of mice to acute hypoxia; (2) rodents with nocturnal activities should pay attention to the effects of circadian rhythm on the research results.