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一、大鼠急性饥饿时血液LH显著降低而垂体LH浓度升高,外源LHRH引起的LH释出和重复给予LHRH时释出反应的增强,则均与饱食者相同。脑室注入氚标记去甲肾上腺素,证明饥饿鼠下丘脑和视前区去甲肾上腺素的更新速度明显降低,α-去甲肾上腺素能受体激动剂可乐停使饥饿鼠血液LH回升到饱食鼠的水平。以上结果表明急性饥饿时垂体生成LH及对LHRH反应的能力并未降低,但中枢去甲肾上腺素递质机制紊乱,LHRH释出障碍以致LH释出不足,可能是血液LH显著降低的主要原因。
First, the rats acute hunger blood LH decreased significantly while pituitary LH concentration increased LH exogenous LHRH LH release and repeated release of LHRH enhanced response, are the same as those who satiety. Intracerebroventricular injection of tritium labeled norepinephrine, to prove starvation hypothalamus and preoptic area norepinephrine update rate was significantly reduced, α-norepinephrine receptor agonist Cola stopped hungry mice blood LH back to fullness Rat level. The above results showed that the pituitary LH and the ability to respond to LHRH did not decrease in acute starvation, but the central norepinephrine neurotransmitter mechanism disorders, LHRH release disorder resulting in LH release may be the main reason for the significant reduction of blood LH.