J.Am.Chem.Soc.2016,138,810~813光学活性α-羟基酮广泛存在于很多具有重要生物活性的分子中,邻羰基酮化合物的不对称还原反应是获得这类化合物最有效的方法之一.目前所报道的例子主要是利用生物催化剂实现邻羰基酮化合物的直接还原,而利用分子催化剂,如过渡金属催化剂的报道还非常少,并且对映选择性不高.中国科学院化学所杜海峰课题组利用手性双炔 J. Am. Chem. Soc. 201 16, 138, 810-813 Optically active alpha-hydroxy ketones are widely found in many molecules with important biological activity and the asymmetric reduction of orthocarbonyl ketones is the most efficient method for obtaining such compounds I. The reported examples are mainly the use of biocatalysts to achieve direct reduction of ortho carbonyl compounds, and the use of molecular catalysts, such as transition metal catalysts is still very little reported, and the enantioselectivity is not high. Chinese Academy of Sciences Du Haifeng Task force to use chiral diacetylene