博莱霉素在治疗过程中容易合并肺毒性,为此,建立了各种动物的博莱霉素肺毒性实验模型。作者认为,用周身给药的方法用药量大,引起肺毒性时间长,而采用药物一次气管内注入的方法可克服上述缺点。本文将博莱霉素多组份复合物以及各组份的末端取代物(侧链):1,4-二氨基丁烷(即A_2′-a的侧链),1,3-二氨基丙烷(A_2′-b侧链)。组胺(A_2′-C侧链)、精脒(A_5侧链)、精胺(A_6侧链)和鲱精胺(B_2侧链)等给小鼠气管内一次注入10～500nM。观察对小鼠肺损害情况。为了排除气管给药对肺的非特异性损害,使用过氧化岐酶(Superoxide dismutase)、维生素C和甲酸胺等作为 Bleomycin susceptible to pulmonary toxicity in the course of treatment, for which, established a model of bleomycin lung toxicity in various animals. The author believes that with the whole body administration of large doses, causing lung toxicity for a long time, and the use of a drug intratracheal injection of the above shortcomings can be overcome. In this paper, bleomycin multi-component complexes as well as the terminal substitutes (side chains) of each component: 1,4-diaminobutane (ie side chain of A_2’-a), 1,3-diaminopropane (A_2’-b side chain). Histamine (A_2’-C side chain), spermidine (A_5 side chain), spermine (A_6 side chain) and herring spermine (B_2 side chain) and other mice were injected once intratracheally 10 ~ 500nM. Observation of lung damage in mice. In order to exclude non-specific damage to lungs by tracheal administration, Superoxide dismutase, Vitamin C and Formamide are used as