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目的观察口服米非司酮联合米索前列醇进行妊娠中期引产的临床效果。方法选取2013年2月—2014年2月安阳市滑县妇幼保健院收治的108例孕妇,按照随机数字表法分为对照组和研究组,每组54例。对照组采用利凡诺尔羊膜腔穿刺注射引产,研究组采用空腹口服米非司酮联合米索前列醇引产。比较两组孕妇的临床表现及引产效果。结果研究组孕妇总产程、宫缩发作时间均短于对照组,产后出血量少于对照组,差异有统计学意义(P<0.05)。研究组孕妇完全引产率高于对照组,差异有统计学意义(P<0.05)。结论口服米非司酮联合米索前列醇进行中期引产的临床效果显著,能有效缩短孕妇的宫缩发作时间及总产程,减少出血量。
Objective To observe the clinical efficacy of oral mifepristone combined with misoprostol for induction of labor during the second trimester of pregnancy. Methods A total of 108 pregnant women admitted to Huaxian MCH Hospital of Anyang City from February 2013 to February 2014 were randomly divided into control group and study group with 54 cases in each group. The control group received rivanol amniocentesis by induction of labor, and the study group adopted fasting oral mifepristone plus misoprostol. The clinical manifestations and induction of labor in two groups were compared. Results The study group maternal total duration of labor, contractions were shorter than the control group, postpartum hemorrhage less than the control group, the difference was statistically significant (P <0.05). The study group pregnant women full induction rate was higher than the control group, the difference was statistically significant (P <0.05). Conclusion Oral mifepristone combined with misoprostol for mid-term induction of labor has a significant clinical effect, which can effectively shorten the maternal uterine contractions and total labor duration and reduce the amount of bleeding.