溃疡性结肠炎 ( UC)是弥散的慢性非特异性炎症性肠病 ,其病因和发病机制至今尚未明确 ,国内外研究多集中于感染、免疫、遗传等因素 ,其中免疫反应异常尤为受到重视。已经证实有许多细胞因子参与结肠粘膜的炎症免疫反应 ,与 UC的发病及转归密切相关。与细胞因子相关的治疗 ,已在 Ulcerative colitis (UC) is a diffuse chronic nonspecific inflammatory bowel disease. The etiology and pathogenesis of UC are still unclear. Most studies at home and abroad focus on factors such as infection, immunity and heredity, of which immunological abnormalities are of particular importance. It has been confirmed that many cytokines are involved in inflammatory reaction of colonic mucosa, which is closely related to the onset and prognosis of UC. Cytokine-related therapies are already there